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What is biological age?

When we talk about age, we usually mean chronological age, which indicates the number of years we have lived. But it is important to realize that the human body is a complex system, and its condition can vary greatly even among people of the same age. This is where epigenetic age comes in handy.

Biological age is based on the latest achievements of genetics and epigenetics, and it allows us to determine the integral state of our organism.

Unlike chronological age, which inevitably increases day by day, biological age reflects our physiological age characteristic related to environmental exposures, lifestyle and genetic traits.

Biological age is measured through the analysis of epigenetic markers, which are certain "marks" on our DNA. These markers reflect changes in gene activity that occur as a result of various factors over the course of a lifetime.

At this point, we know that biological age improves with:

There are over 8,000 studies that showed cause-and-effect relationship of all kinds of interventions on biological age.
Most of them show impact on epigenetic age.

Socioeconomic status (Fiorito G, Aging, 2019)

Lifestyle changes (Fitzgerald KN, et al., 2021)

Physical activity (Foster, et al. Lancet Public
Health. 2018)

Lifestyle habits (Fiorito G, et al., Aging, 2019)

Healthy eating (Quach A, et al., Aging, 2017)

Giving up bad habits (Kim, K., et al. Clin Epigenet, 2022)

Science behind the Epigee test

The relationship between epigenetic age and the hallmarks of aging in human cells

Sylwia Kabacik, Donna Lowe, Leonie Fransen, Martin Leonard, Siew-Lan Ang, Christopher Whiteman, Sarah Corsi, Howard Cohen, Sarah Felton, Radhika Bali, Steve Horvath & Ken Raj

May, 2022

Epigenetic clock: a promising mirror of ageing

Zuyun Liu, Yimin Zhu

May, 2021

A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration

Lara Oblak, Jeroen van der Zaag, Albert T. Higgins-Chen, Morgan E. Levine, Marco P. Boks

August, 2021

DNA Methylation, Aging, and Cancer Risk: A Mini-Review

Larry Chen, Patricia A. Ganz, Mary E. Sehl

June, 2022

The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis

Peter D. Fransquet, Jo Wrigglesworth, Robyn L. Woods, Michael E. Ernst & Joanne Ryan

April, 2019

Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women

Purva Jain, PhD, MPH; Alexandra M. Binder, ScD, ScM; Brian Chen, PhD; et al

July, 2022

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Biological age and DNA testing service

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